ABSTRACT

Objective: To evaluate the impact of asthma on activities of daily living and on health status in patients with controlled, partially controlled, or uncontrolled asthma in Brazil. Methods: We used data related to 400 patients in four Brazilian cities (São Paulo, Rio de Janeiro, Salvador, and Curitiba), obtained in a survey conducted throughout Latin America in 2011. All study subjects were > 12 years of age and completed a standardized questionnaire in face-to-face interviews. The questions addressed asthma control, hospitalizations, emergency room visits, and school/work absenteeism, as well as the impact of asthma on the quality of life, sleep, and leisure. The level of asthma control was determined in accordance with the Global Initiative for Asthma criteria. Results: Among the 400 respondents, asthma was controlled in 37 (9.3%), partially controlled in 226 (56.5%), and uncontrolled in 137 (34.2%). The numbers of patients with uncontrolled or partially controlled asthma who visited the emergency room, who were hospitalized, and who missed school/work were higher than were those of patients with controlled asthma (p = 0.001, p = 0.05, and p = 0.01, respectively). Among those with uncontrolled asthma, the impact of the disease on activities of daily living, sleep, social activities, and normal physical exertion was greater than it was among those with controlled or partially controlled asthma (p < 0.001). Conclusions: In Brazil, asthma treatment should be monitored more closely in order to increase treatment adherence and, consequently, the level of asthma control, which can improve patient quality of life and minimize the negative impact of the disease.

RESUMO

Objetivo: Avaliar o impacto da asma nas atividades da vida diária e na saúde em pacientes com asma controlada, parcialmente controlada ou não controlada no Brasil. Métodos: Foram utilizados dados de 400 pacientes de quatro cidades brasileiras (São Paulo, Rio de Janeiro, Curitiba e Salvador) obtidos em um inquérito realizado em países da América Latina em 2011. Todos os indivíduos do estudo tinham idade > 12 anos e responderam a um questionário padronizado por meio de entrevista presencial. As questões abordavam o controle da asma, número de hospitalizações, de consultas de urgência, absenteísmo na escola/trabalho e impacto da asma na qualidade de vida, sono e lazer. O nível de controle da asma foi verificado segundo os critérios da Global Initiative for Asthma. Resultados: Entre 400 entrevistados, a asma estava controlada em 37 (9,3%); parcialmente controlada, em 226 (56,5%); e não controlada, em 137 (34,2%). O número de pacientes com asma não controlada ou parcialmente controlada que apresentaram hospitalizações, visitas ao pronto-socorro e faltas na escola/trabalho foi maior do que o daqueles com asma controlada (p = 0,001, p = 0,05 e p = 0,01, respectivamente). Os participantes com asma não controlada apresentaram um maior impacto da doença em atividades da vida diária, sono, atividades sociais e esforço físico normal do que aqueles com asma parcialmente controlada ou controlada (p < 0,001). Conclusões: Medidas terapêuticas devem ser mais intensamente adotadas em nosso país para melhorar o controle da asma e estimular a aderência ao tratamento. Isso, seguramente, proporcionará uma melhor qualidade de vida aos pacientes e uma redução do impacto negativo da doença.

Palavras-chave: Asma/epidemiologia; Qualidade de vida; Hospitalização.

Introduction

Asthma is a chronic disease that is highly prevalent in Brazil.(1,2) According to the International Study of Asthma and Allergies in Childhood,(3) the prevalence of asthma in Brazil is approximately 20% among children (6-7 years of age) and adolescents (13-14 years of age), varying by region. This rate is one of the highest in Latin America.(2-4) The prevalence of wheezing in the last 12 months can range from 11.8% to 30.5% among adolescents, depending on the region of Brazil.(3) In addition to its high prevalence, asthma is the fourth leading cause of hospitalization via the Brazilian Unified Health Care System.(1,2)

The negative impact of asthma is usually estimated on the basis of mortality, number of asthma attacks, and number of hospitalizations. However, the effects of asthma can impair other important aspects, such as the quality of life and physical well-being of patients, and can affect performance at school or work.(5,6) In 2003, the Asthma Insights and Reality in Latin America (AIRLA) survey was carried out in order to evaluate the quality of treatment and the impact of asthma in Latin America. At the time, 52% of the adults with asthma were found to have been to the emergency room or to have been hospitalized at least once in the previous year, demonstrating the major impact of this disease. In addition, 31% reported having missed work at least once because of an asthma attack. Likewise, asthma had an impact on children, with 58% having missed school in the previous year.(7)

Although there is effective treatment for asthma, all these negative effects on the individual affected are triggered by poor disease control and lack of self-management training. Currently, the level of asthma control is determined in accordance with the Global Initiative for Asthma (GINA) criteria.(8) Asthma patients are classified as having controlled, partially controlled, or uncontrolled asthma on the basis of symptoms, limitations in activities of daily living, nocturnal awakenings, use of rescue medication, and pulmonary function.(8) In recent years, GINA has constantly updated its criteria, and the Brazilian Thoracic Association has developed guidelines for the management of asthma,(2) both groups seeking to disseminate the concept of asthma and its treatment and control. Therefore, it is important to know what impact asthma has had on subjects affected by the disease and what their level of asthma control is so that appropriate measures can be implemented to ensure that the disease is controlled in the maximum possible number of subjects. The objective of the present study was to evaluate the impact of asthma in patients in Brazil by level of disease control.

Methods

The Latin America Asthma Insight and Management (LA AIM) survey was designed to assess and document patient perception of disease control, patient knowledge of the disease, and treatment modality. The survey was developed following the same methods used in the Asthma Insight and Management (AIM) surveys conducted in the USA, Europe, Canada, Asia, and the Pacific region. The LA AIM survey was conducted in Argentina, Brazil, Mexico, Venezuela, and Puerto Rico.

Initially, 4,545 households in four Brazilian cities (São Paulo, Rio de Janeiro, Curitiba, and Salvador) were selected from a national probability sample. If there were two or more subjects with asthma in the household, one of them was randomly selected, and a home visit was scheduled over the telephone. A total of 400 patients who reported having physician-diagnosed asthma were interviewed in person (Figure 1); the patients who were 18 years of age or older were interviewed directly, as were the parents of the adolescents between 12 and 17 years of age. The interviews lasted approximately 35 minutes. The questionnaire consisted of 53 questions that addressed five major asthma domains: symptoms; impact of asthma on life; perception of asthma control; exacerbations; and treatment/medication.



In order to evaluate the negative impact of asthma on the daily life of respondents, the questions addressed the frequency of school or work absences due to asthma, limitation in activities because of the disease, productivity levels on days when experiencing an asthma attack, and the influence of asthma on the quality of life. Respondents were also asked whether they or their children had been hospitalized or had been to the emergency room in the last 12 months and, if so, how many times. In addition, respondents were asked whether they had sought a physician for exacerbations, symptoms of worsening disease, and severe asthma attacks in the previous year.

Respondents were required to classify their (or their child's) level of asthma control in the last four weeks and in the previous year. These levels of asthma control were subsequently compared with the GINA criteria.

All data were provided by a large pharmaceutical company, and, since we did not have any personal contact with the respondents, the Research Ethics Committee of the Federal University of São Paulo decided that protocol approval was not necessary for the present study.

In the statistical analysis, categorical variables are presented as absolute numbers and percentages, and continuous variables are presented as mean and standard deviation. The chi-square test was used for the comparison of categorical variables among the groups studied (controlled, partially controlled, and uncontrolled asthma), and ANOVA was used for the comparison of means. In order to analyze the questions related to the impact of asthma on sports, normal physical exertion, social activities, and sleep, as well as to its interference with life, each of the questions received a score ranging from 1 (high interference of asthma with daily life) to 4 (no interference of asthma), and these values are presented as mean and standard deviation. Tukey's post hoc test was used, and the level of significance was set at p < 0.05.

Results

A total of 400 asthma patients were interviewed in four Brazilian cities: São Paulo (47.8%), Rio de Janeiro (36.0%), Curitiba (7.0%), and Salvador (9.2%). Among the 400 respondents, asthma was controlled in 37 (9.3%), partially controlled in 226 (56.5%), and uncontrolled in 137 (34.2%), as determined in accordance with the GINA criteria.

The patients with controlled asthma were younger than those with uncontrolled or partially controlled asthma (p = 0.03). There was a higher proportion of females among those with uncontrolled asthma than among those with controlled or partially controlled asthma (Table 1). The three groups showed no differences in terms of the presence of smokers or pets in the household (Table 1).



Among the patients with uncontrolled or partially controlled asthma, the negative impact of the disease on health status was greater. This can be seen in Table 2, which shows that the numbers of patients with uncontrolled or partially controlled asthma who visited the emergency room, who were hospitalized, and who missed school or work were higher than were those of patients with controlled asthma. However, there were no differences in the number of patients admitted to the ICU. As can be seen in Table 2, the number of patients who did not receive maintenance medication in the last four weeks was very high.



Among the patients with uncontrolled or partially controlled asthma, the impact of the disease on their daily life was greater. The scores for the questions related to normal physical exertion, social activities, sleep, sports/recreation, and interference with life were (statistically significantly) lower among those with uncontrolled asthma than among those with controlled or partially controlled asthma; likewise, the scores for those same questions were lower among those with partially controlled asthma than among those with controlled asthma, except for the question related to sports/recreation, for which there was no significant difference (Table 3).



Discussion

Although current guidelines suggest that the main goal of asthma treatment is to achieve adequate disease control(9) and to reduce future risk of exacerbations,(10) the results of the present study demonstrate that only 9.3% of the asthma patients interviewed had controlled asthma, as determined in accordance with the GINA criteria. The proportions of patients with uncontrolled or partially controlled asthma who visited the emergency room (57.5% and 62.0%, respectively), who were hospitalized (23.0% and 39.4%, respectively), and who missed work or school (36.3% and 46.7%, respectively) were higher than were those of patients with controlled asthma. Likewise, the negative impact on sports, normal physical exertion, social activities, sleep, and quality of life was greater.

The present study had a lower proportion of subjects with controlled asthma than did the AIM survey conducted in the USA (9.3% vs. 26.0%).(11) One of the reasons that could explain this lower proportion than that found in the USA is poor adherence to pharmacological treatment in Brazil. A prospective one-year follow-up study involving children attending a referral outpatient clinic in the city of Belo Horizonte, Brazil, revealed that, of those with uncontrolled asthma, only 49.6% were adherent to treatment at 4 months of treatment, compared with 86.6% of those with controlled asthma. This generated a proportion of 62.3% of patients with clinically uncontrolled asthma, and an adherence rate of 80% to the use of medication was the cut-off point for achieving asthma control.(12) In addition, the proportion of patients with controlled asthma found in that study was lower than that reported in a study conducted in the city of Porto Alegre, Brazil, in which 17.5% of the subjects were classified as having controlled asthma.(13) This discrepancy observed between our findings and national data might be due to the fact that, in the study conducted in Porto Alegre, the patients attended a referral asthma outpatient clinic, unlike in our study, in which the sample was randomized and included four Brazilian cities, which should correspond more closely to what is observed in real life. It is of note that only 5.4% of the subjects with controlled asthma in our study used maintenance medication. This leads us to believe that our study subjects had very mild asthma. In addition, it is known that, in order to achieve optimal asthma control at a population level, there should be programs aimed at full treatment of patients and their comorbidities, such as allergic rhinitis.(14,15) However, the proportion of patients with uncontrolled asthma found in our study (34.2%) was very similar to that reported in the AIM survey conducted in the USA (30.0%).(9)

High numbers of emergency room visits, hospitalizations, ICU admissions, and school/work absences are known to be directly related to failure to control asthma. Therefore, as expected, the proportion of patients who were hospitalized was found to be higher among those with uncontrolled or partially controlled asthma than among those with controlled asthma in the present study, ranging from 8.1% among those with controlled asthma to 39.4% among those with uncontrolled asthma. Also, as in other studies, we found that patients with uncontrolled or partially controlled asthma are at higher risk for hospitalization.(16-18) The proportion of patients who visited the emergency room was also higher among those with uncontrolled or partially controlled asthma (57.5% and 62.0%, respectively) than among those with controlled asthma (35.1%). High proportions of patients who visited the emergency room and of patients who were hospitalized were also found in a survey conducted in the USA, in which more than half of the patients reported having been to the emergency room for asthma, and nearly one third of the patients reported having been hospitalized for asthma at some point in their life.(19)

In addition to the clinical, functional, and psychological consequences that asthma attacks and hospitalizations have on subjects with asthma, there is the increase in the use of health resources and, consequently, in the costs of the disease. A recent study has demonstrated that subjects with uncontrolled asthma use more health resources than do those with controlled asthma.(20) In the present study, school absenteeism was higher among the patients with uncontrolled or partially controlled asthma (36.3% and 46.7%, respectively) than among those with controlled asthma (16.2%); however, these values are lower than that found in the AIRLA survey, in which 58% of the children interviewed reported having missed school because of an asthma attack.(7) Asthma symptoms can affect activities of daily living, as well as contributing to school absenteeism. A study conducted in California, USA, found that asthma accounted for approximately 1.9 million lost school days and 2 million lost workdays in 2005. School-age children (4-17 years of age) with daily or weekly asthma symptoms were at higher risk of missing school for at least one week in the last 12 months because of their asthma (28%) than were children who had asthma symptoms less than once a month (15%). Adults with asthma were at risk of missing work for at least one week in the previous year because of their asthma, this risk being twice as high among those with daily or weekly symptoms (12%) compared with those who had symptoms less than once a month (5%).(21) Work absenteeism is directly related to reduced productivity. Consequently, this reduction promotes an increase in the indirect costs of the disease, leading to higher costs to employers and the government.


Among subjects with uncontrolled or partially controlled asthma, the impact of asthma on daily life is greater than it is among those with controlled asthma. They report that asthma interferes with sports, normal physical exertion, social activities, sleep, and overall quality of life "a little", which demonstrates the importance of monitoring these patients. Many negative consequences caused by asthma could be mitigated by early diagnosis, medical care, treatment follow-up, and education programs for patients, family members, and health professionals.(22)

Education programs should be based on guidelines, should be associated with medical treatment, and should have a multidisciplinary approach.(2) After interventions, which include education on the disease, the correct use of the medication, identification of asthma triggers, environmental prophylactic measures, and signs of good and poor asthma control, patients experience improvement in overall quality of life and its components (physical limitation, frequency of symptoms, and treatment adherence).(23) A study on the implementation of a short-term education program for children with asthma demonstrated that the program succeeded in increasing participants' knowledge of asthma, allaying fears and correcting misconceptions about asthma treatment and control.(23)

The impact of asthma in the USA remained virtually unchanged between 1998 and 2009. There were some improvements in the identification of symptoms and symptom-related limitations, but little change occurred in asthma treatment adherence. Patients still have inadequate understanding of the meaning of adequate asthma control.(24) Our data show that, 9 years after the AIRLA survey, only a low proportion of patients keep their asthma under control.

The method used in the present study was the same as that used in important studies, such as the AIM survey conducted in the USA and the LA AIM survey, and was similar to that used in the AIRLA survey.(7) However, our study has some limitations. Although four important Brazilian cities were included in the present study, it is possible that they do not represent the population with asthma in Brazil. Nevertheless, it is unlikely that studies with this type of design can cover the entire population of a country. The fact that the four cities are located in different regions of Brazil can somewhat mitigate this limitation.

Another limitation of this study is that we did not have data on pulmonary function measured by spirometry, a test that is also a part of staging requirements for the definition of disease control; an FEV1 < 70% of predicted is one of the criteria for classifying asthma as uncontrolled. However, knowing that the disease is not controlled only on the basis of the questionnaire is enough of a warning to our health care system, given that the proportion of patients was high. Finally, these data were obtained from self-reports, i.e., they were not extracted from medical records.


We conclude that approximately only 10% of the population of asthma patients in Brazil have controlled asthma, as determined in accordance with the GINA criteria. In addition, the numbers of patients with uncontrolled or partially controlled asthma who visited the emergency room and who missed work or school were higher than were those of patients with controlled asthma, and the impact of the disease on daily activities was greater among the former. Since free treatment for asthma patients is already available in Brazil, the finding that asthma is not controlled in 90% of patients implies that, in our country, asthma treatment should be monitored more closely in order to increase treatment adherence and, consequently, the level of asthma control. This can improve patient quality of life and minimize the negative impact of the disease.

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Study carried out at the Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil.
Correspondence to: José Roberto Jardim. Rua Botucatu, 740, 3º andar, Pneumologia UNIFESP/EPM, CEP 04021-032,
São Paulo, SP, Brasil.
Tel. 55 11 5572-4301. E-mail: jardimpneumo@gmail.com
Financial support: This study received financial support from Merck, Sharp & Dohme Corp., which also provided the data for the study.
Submitted: 15 February 2013. Accepted, after review: 12 August 2013.




About the authors

Mariana Rodrigues Gazzotti
Professor. Federal University of São Paulo/Paulista School of Medicine and São Camilo University Center, São Paulo, Brazil.

Oliver Augusto Nascimento
Attending Pulmonologist. Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil.

Federico Montealegre
Medical Director. Merck, Sharp & Dohme Corp., Carolina, PR, USA; and Professor. School of Public Health, University of Puerto
Rico, Reio Piedras, PR, USA

James Fish
Global and Scientific Affairs. Merck, Sharp & Dohme Corp., Whitehouse Station, NJ, USA.

José Roberto Jardim
Tenured Professor of Pulmonology, Federal University of São Paulo/Paulista School of Medicine, São Paulo, Brazil.