Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Evolution of performance status, body mass index, and six-minute walk distance in advanced lung cancer patients undergoing chemotherapy

Evolução do status de performance, índice de massa corpórea e distância percorrida no teste de caminhada de seis minutos em pacientes com câncer de pulmão avançado submetidos à quimioterapia

Luciana Machado, Ivete Alonso Bredda Saad, Helen Naemi Honma, André Moreno Morcillo, Lair Zambon

J Bras Pneumol.2010;36(5):588-594

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Objective: To evaluate the effect of chemotherapy on the physical condition of patients with advanced lung cancer. Methods: We evaluated 50 patients with non-small cell lung cancer (in stages IIIB and IV) and Eastern Cooperative Oncology Group (ECOG) performance status scale scores between zero and two. All patients underwent chemotherapy using paclitaxel and platinum derivatives and were evaluated at three time points (prechemotherapy, postchemotherapy and six months after starting the treatment), at which the ECOG scale, the body mass index (BMI) and the six-minute walk distance (6MWD) were assessed. Results: Of the 50 patients included in the study, 14 died, 5 were excluded due to the worsening of their performance status, and 31 completed the six-month follow-up. There was no statistically significant difference between the time points of assessment for BMI (prechemotherapy vs. postchemotherapy, p = 1.00; and prechemotherapy vs. six months later, p = 0.218) or for 6MWD. Performance status improved, and this was especially due to the increase in the number of asymptomatic patients after the six-month follow-up (p = 0.031). Conclusions: Chemotherapy had a beneficial effect on the performance status of the patients. No significant changes in BMI or 6MWD were found during the study period, which might suggest the maintenance of the physical condition of the patients.

 


Keywords: Drug therapy; Lung neoplasms; Exercise tolerance.

 


Alveolar hemorrhage after parenteral injection of industrial silicone

Hemorragia alveolar após injeção parenteral de silicone industrial

Ronaldo Ferreira Macedo, Ricardo Ananias Lobão, Eduardo Mello De Capitani, Maira Eliza Petrucci Zanovello, Paula Catarina Caruso, Maurício Souza de Toledo Leme, Elza Maria Figueiras Pedreira de Cerqueira, Lair Zambon

J Bras Pneumol.2013;39(3):387-389

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Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake

Insuficiência respiratória aguda como manifestação da síndrome de eosinofilia-mialgia associada à ingestão de L-triptofano

Tiago de Araujo Guerra Grangeia, Marcelo Schweller, Ilma Aparecida Paschoal, Lair Zambon, Mônica Corso Pereira

J Bras Pneumol.2007;33(6):747-751

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Eosinophilia-myalgia syndrome was described in 1989 in patients who presented progressive and incapacitating myalgia and eosinophilia in blood, fluids and secretions. Most patients report previous L-tryptophan intake. Respiratory manifestations are found in up to 80% of the cases, occasionally as the only manifestation. Treatment includes drug discontinuation and administration of corticosteroids. Here, we describe the case of a 61-year-old female admitted with acute respiratory failure after using L-tryptophan, hydroxytryptophan and other drugs. The patient presented eosinophilia, together with elevated eosinophil counts in the bronchoalveolar lavage and pleural effusion. After discontinuation of the drugs previously used, corticosteroids were administered, resulting in clinical and radiological improvement within just a few days.

 


Keywords: Respiratory insufficiency; Tryptophan; Eosinophilia-myalgia syndrome.

 


Polymorphism of the CYP1A1*2A gene and susceptibility to lung cancer in a Brazilian population

O polimorfismo do gene CYP1A1*2A e a suscetibilidade ao câncer de pulmão na população brasileira

Helen Naemi Honma, Eduardo Mello De Capitani, Aristóteles de Souza Barbeiro, Daniel Botelho Costa, André Morcillo, Lair Zambon

J Bras Pneumol.2009;35(8):767-772

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Objective: To estimate and compare the frequency of CYP1A1*2A gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to lung cancer risk. Methods: The study population included 200 patients with lung cancer, and the control group consisted of 264 blood donors. Genomic DNA was obtained from peripheral blood samples. The PCR-RFLP method was used for analysis of the CYP1A1*2A gene. Results: There was no statistically significant difference between the lung cancer patients and the controls in terms of the distribution of CYP1A1*2A polymorphisms (p = 0.49). A multivariate logistic regression model analysis by ethnic group revealed that, within the lung cancer group, the CYP1A1*2A genotype CC plus TC was more common among the African-Brazilian patients than among the White patients (adjusted OR = 3.19; 95% CI: 1.53‑6.65). Conclusions: The CYP1A1*2A gene cannot be linked with lung cancer risk in Brazilian patients at this time. Larger epidemiologic studies are needed in order to establish whether the CC plus TC polymorphism increases the risk of lung cancer in African-Brazilians.

 


Keywords: Lung neoplasms; Polymorphism, genetic; Metabolism.

 


Response to cytotoxic chemotherapy and overall survival in non-small cell lung cancer patients with positive or negative ERCC1 expression

Resposta à quimioterapia citotóxica e sobrevida global em pacientes com câncer de pulmão não pequenas células com expressão positiva ou negativa para ERCC1

Helen Naemi Honma1,a, Maurício Wesley Perroud Jr1,b, André Moreno Morcillo2,c, José Vassallo3,d, Lair Zambon1,e

J Bras Pneumol.2018;44(3):245-246

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