Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Publication continuous and bimonthly

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An update on the use of antifungal agents

Atualização no uso de agentes antifúngicos

Roberto Martinez

J Bras Pneumol.2006;32(5):449-460

Abstract PDF PT PDF EN Portuguese Text

We summarize here data regarding the spectrum of action, the pharmacological aspects, the toxicological aspects and the clinical efficacy of liposomal amphotericin B, amphotericin B in colloidal dispersion, amphotericin B lipid complex, voriconazole and caspofungin. We discuss the use of these more recently introduced antifungal agents in terms of their safety, efficiency and cost. We also offer suggestions for the clinical use of these drugs in pulmonary and systemic infections, with an emphasis on the lower toxicity of the lipid formulations of amphotericin B in comparison with conventional medications. In addition, we explore the possibility of using voriconazole as the primary treatment for invasive infections such as aspergillosis, as well as those caused by Scedosporium spp. and Fusarium spp., together with that of using caspofungin to treat disseminated candidiasis and invasive aspergillosis.

 


Keywords: Aspergillosis; Lung diseases, fungal/drug therapy; Amphotericin b/administration & dosage;

 


Primary complex of paracoccidioidomycosis and hypereosinophilia

Complexo primário da paracoccidioidomicose e hipereosinofilia

Roberto Martinez, Maria Janete Moya

J Bras Pneumol.2009;35(12):-

Abstract PDF PT PDF EN Portuguese Text

Primary infection with Paracoccidioides brasiliensis has rarely been observed. A 28-year-old male patient presented with a three-month history of fever, respiratory symptoms and malaise. Chest X-rays revealed bilateral apical infiltrates, right pleuritis and hilar lymphadenomegaly. The patient presented with leukocytosis, severe eosinophilia and increasing titers of anti-P. brasiliensis antibodies in serum. To our knowledge, this is the first report of the primary pulmonary lymph node complex of paracoccidioidomycosis accompanied by hypereosinophilia and affecting a previously healthy adult.

 


Keywords: Paracoccidioidomycosis; Eosinophilia; Lung diseases, fungal.

 


Pneumococcal resistance to penicillin and macrolides: implications for the treatment of respiratory infections

Resistência do pneumococo à penicilina e aos macrolídeos: implicações no tratamento das infecções respiratórias

Roberto Martinez

J Bras Pneumol.2005;31(4):4-5

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CNPq, Capes, Ministério da Educação, Ministério da Ciência e Tecnologia, Governo Federal, Brasil, País Rico é País sem Pobreza
Secretariat of the Brazilian Journal of Pulmonology
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E-mails: jbp@jbp.org.br
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