Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Myositis-related interstitial lung disease and antisynthetase syndrome

Doença pulmonar intersticial relacionada a miosite e a síndrome antissintetase

Joshua Solomon, Jeffrey J. Swigris, Kevin K. Brown

J Bras Pneumol.2011;37(1):100-109

Abstract PDF PT PDF EN Portuguese Text

In patients with myositis, the lung is commonly involved, and the presence of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies marks the presence or predicts the development of interstitial lung disease (ILD). A distinct clinical entity-antisynthetase syndrome-is characterized by the presence of anti-ARS antibodies, myositis, ILD, fever, arthritis, Raynaud's phenomenon, and mechanic's hands. The most common anti-ARS antibody is anti-Jo-1. More recently described anti-ARS antibodies might confer a phenotype that is distinct from that of anti-Jo-1-positive patients and is characterized by a lower incidence of myositis and a higher incidence of ILD. Among patients with antisynthetase syndrome-related ILD, the response to immunosuppressive medications is generally, but not universally, favorable.

 


Keywords: Lung diseases, interstitial; Pneumonia; Infection.

 


 

 


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