Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Postinfectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in childhood

Associação de bronquiolite obliterante pós-infecciosa e hemossiderose pulmonar na infância

Leonardo Araújo Pinto, Anick Oliveira, Sintia Collaziol, Paulo Márcio Pitrez, Marcus Jones, João Carlos Prolla, Marisa Dolhnikoff, Renato T. Stein

J Bras Pneumol.2006;32(6):587-591

Abstract PDF PT PDF EN Portuguese Text

In the present report, we describe an unusual presentation of post-infectious bronchiolitis obliterans accompanied by pulmonary hemosiderosis in a nine-year-old boy with persistent respiratory symptoms subsequent to an episode of acute bronchiolitis occurring at the age of seven months. After the episode, the persistent respiratory symptoms worsened significantly, and, by the age of seven, the patient began to have difficulty breathing after minimal exertion. Computed tomography of the chest presented findings consistent with bronchiolitis obliterans. Open lung biopsy revealed numerous hemosiderin-laden macrophages, as well as other findings consistent with bronchiolitis obliterans. Pulmonary hemosiderosis can occasionally be accompanied by bronchiolitis obliterans in children with severe sequelae after an episode of viral infection.

 


Keywords: Bronchoalveolar lavage; Bronchiolitis obliterans; Hemosiderosis; Case reports [Publication type]

 


Lymphadenopathy and fever in a chef during a stay in Europe

Linfadenomegalia e febre em chefe de cozinha durante viagem à Europa

Letícia Kawano-Dourado, Daniel Antunes Silva Peirera, Alexandre de Melo Kawassaki, Marisa Dolhnikoff, Marcos Vinicius da Silva, Ronaldo Adib Kairalla

J Bras Pneumol.2015;41(2):191-195

Abstract PDF PT PDF EN Portuguese Text

This case illustrates a rare presentation (as lymphadenopathy and fever) of one of the most common zoonotic diseases worldwide-brucellosis-in a 22-year-old Brazilian male (a chef) who had recently returned to Brazil after having lived in and traveled around Europe for one year. The histopathology, clinical history, and response to treatment were all consistent with a diagnosis of brucellosis, which was confirmed by PCR in a urine sample. We also review some aspects of brucellosis, such as the clinical features, diagnosis, and management.

 


Keywords: Brucellosis; Fever; Lymph nodes; Brucella; Mononuclear phagocyte system; Granuloma.

 


Bronchial remodeling in asthma

Remodelamento brônquico na asma

Thais Mauad, Alessandra Sandrini Lopes de Souza, Paulo Hilário Nascimento Saldiva, Marisa Dolhnikoff4

J Bras Pneumol.2000;26(2):91-98

Abstract PDF PT

The relationship between structure and function in asthma has been extensively studied. All the compartments of the airway have been shown to have some structural alterations contributing to functional defects. The structural alterations are thought to be a consequence of the chronic inflammation present in asthmatic airways, leading ultimately to remodeling. The decline of the ventilatory function over time in some asthmatic patients may be a consequence of airway remodeling. In this review, the authors describe the phenomena leading to airway remodeling and discuss the role of inflammatory mediators involved in this process. The structural alterations of the asthmatic airways are presented and the possible correlated functional defects are discussed.

 


Keywords: bronchii; pathology; asthma.

 


 

 


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