Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Ex vivo lung perfusion in Brazil

A experiência brasileira na perfusão pulmonar ex vivo

Luis Gustavo Abdalla1, Karina Andrighetti de Oliveira Braga1, Natalia Aparecida Nepomuceno1, Lucas Matos Fernandes1, Marcos Naoyuki Samano1, Paulo Manuel Pêgo-Fernandes1

J Bras Pneumol.2016;42(2):95-99

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Objective: To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. Methods: A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for up to 4 h each. During EVLP, respiratory mechanics were continuously evaluated. Once every hour during the procedure, samples of the perfusate were collected and the function of the lungs was evaluated. Results: The mean PaO2 of the recovered lungs was 262.9 ± 119.7 mmHg at baseline, compared with 357.0 ± 108.5 mmHg after 3 h of EVLP. The mean oxygenation capacity of the lungs improved slightly over the first 3 h of EVLP-246.1 ± 35.1, 257.9 ± 48.9, and 288.8 ± 120.5 mmHg after 1, 2, and 3 h, respectively-without significant differences among the time points (p = 0.508). The mean static compliance was 63.0 ± 18.7 mmHg, 75.6 ± 25.4 mmHg, and 70.4 ± 28.0 mmHg after 1, 2, and 3 h, respectively, with a significant improvement from hour 1 to hour 2 (p = 0.029) but not from hour 2 to hour 3 (p = 0.059). Pulmonary vascular resistance remained stable during EVLP, with no differences among time points (p = 0.284). Conclusions: Although the lungs evaluated remained under physiological conditions, the EVLP protocol did not effectively improve lung function, thus precluding transplantation.

 


Keywords: Lung transplantation; Organ preservation; Brain death; Donor selection.

 


Lung transplantation with extracorporeal membrane oxygenation as intraoperative support

Transplante pulmonar com oxigenação extracorpórea por membrana como suporte intraoperatório

Mariana Schettini-Soares1,a, Pedro Henrique Cunha Leite1,b, Ludhmila Abrahão Hajjar2,c, André Nathan Costa3,d, Paulo Manuel Pêgo-Fernandes1,e, Marcos Naoyuki Samano1,f

J Bras Pneumol.2018;44(5):442-444

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Lung transplantation: overall approach regarding its major aspects.

Transplante pulmonar: abordagem geral sobre seus principais aspectos.

Priscila Cilene León Bueno de Camargo1, Ricardo Henrique de Oliveira Braga Teixeira1, Rafael Medeiros Carraro1, Silvia Vidal Campos1, José Eduardo Afonso Junior1, André Nathan Costa1, Lucas Matos Fernandes1, Luis Gustavo Abdalla1, Marcos Naoyuki Samano1, Paulo Manuel Pêgo-Fernandes1,2

J Bras Pneumol.2015;41(6):547-553

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CNPq, Capes, Ministério da Educação, Ministério da Ciência e Tecnologia, Governo Federal, Brasil, País Rico é País sem Pobreza
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