Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713


Publication continuous and bimonthly

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Hereditary hemorrhagic telangiectasia: a rare cause of severe anemia

Telangiectasia hemorrágica hereditária: uma causa rara de anemia grave

José Wellington Alves dos Santos, Tiago Chagas Dalcin, Kelly Ribeiro Neves, Keli Cristina Mann, Gustavo Luis Nunes Pretto, Alessandra Naimaier Bertolazi

J Bras Pneumol.2007;33(1):109-112

Abstract PDF PT PDF EN

Hereditary hemorrhagic telangiectasia is an autosomal dominant disease in which arteriovenous communications are typically seen in the skin, mucosal surfaces, lungs, brain and gastrointestinal tract. This disease typically presents as epistaxis, gastrointestinal bleeding and arteriovenous malformations (in the brain and lungs). Although the epistaxis and gastrointestinal bleeding can result in anemia, patients diagnosed with hereditary hemorrhagic telangiectasia rarely present severe anemia. Herein, we report the case of a 49-year-old man with severe anemia and undiagnosed hereditary hemorrhagic telangiectasia.


Keywords: Hereditary hemorrhagic telangiectasia; Iron deficiency anemia; Case reports [publication type].


Endobronchial granular cell tumor: report of a case diagnosed by endoscopic biopsy

Tumor de células granulares endobrônquico: relato de um caso diagnosticado por biópsia endoscópica

Ayrton Schneider Filho, Carlos Renato Almeida Melo, Alessandra Naimaier Bertolazi, Carlos Eurico da Luz Pereira

J Bras Pneumol.2002;28(1):51-54

Abstract PDF PT

Granular cell tumor (GCT) is a term used to describe a tumor with distinctive histology, characteristic immunohistochemical profile, and peculiar ultrastructural findings. This tumor has an ample topographic distribution and its localization in the airways is considered common. The authors report on the case of a 40-year old woman who had been presenting productive cough and fever for two months and seemed normal at physical examination. Computerized tomography evidenced thickened intermediary bronchial wall and bronchoscopy showed, at this level, hyperemia and elevation of the endobronchial mucosa. Histopathological and immunohistochemical examination of the tissued established the diagnosis of GCT. The purpose of this report is to call attention to the possibility of diagnosing this kind of tumor by small endoscopic biopsies.


Keywords: Neoplasm muscle tissue. Granular cell tumor. Biopsy. Diagnosis


Portuguese-language version of the Epworth sleepiness scale: validation for use in Brazil

Validação da escala de sonolência de Epworth em português para uso no Brasil

Alessandra Naimaier Bertolazi, Simone Chaves Fagondes, Leonardo Santos Hoff, Vinícius Dallagasperina Pedro, Sérgio Saldanha Menna Barreto, Murray W. Johns

J Bras Pneumol.2009;35(9):877-883

Abstract PDF PT PDF EN Portuguese Text

Objective: The aim of this study was to develop a Portuguese-language version of the Epworth sleepiness scale (ESS) for use in Brazil. Methods: The steps involved in creating the ESS in Brazilian Portuguese (ESS-BR) were as follows: translation; back-translation; comparison (by a committee) between the translation and the back-translation; and testing in bilingual individuals. The ESS-BR was applied to a group of patients who were submitted to overnight polysomnography in order to identify obstructive sleep apnea-hypopnea syndrome (OSAHS), insomnia and primary snoring. A control group was composed of subjects with a history of normal sleep habits, without reported snoring. Results: A total of 114 patients and 21 controls were included. The 8-item scores of the ESS-BR had an overall reliability coefficient of 0.83. The study group was composed of 59 patients with OSAHS, 34 patients with primary snoring and 21 patients with insomnia. One-way ANOVA demonstrated significant differences in ESS-BR scores among the four diagnostic groups (p < 0.001). Post-hoc tests between groups showed that the ESS-BR scores of the patients with insomnia did not differ from those of the controls (p > 0.05). The ESS-BR scores were significantly higher for OSAHS patients and for primary snorers than for controls (p < 0.05). In addition, the scores for OSAHS patients were significantly higher than were those for primary snorers (p < 0.05). Conclusions: The results of the present study demonstrate that the ESS-BR is a valid and reliable instrument for the assessment of daytime sleepiness, equivalent to its original version when applied to individuals who speak Brazilian Portuguese.


Keywords: Validation studies; Sleep disorders; Cross-cultural comparison; Disorders of excessive somnolence.




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