Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Ex vivo lung perfusion in Brazil

A experiência brasileira na perfusão pulmonar ex vivo

Luis Gustavo Abdalla1, Karina Andrighetti de Oliveira Braga1, Natalia Aparecida Nepomuceno1, Lucas Matos Fernandes1, Marcos Naoyuki Samano1, Paulo Manuel Pêgo-Fernandes1

J Bras Pneumol.2016;42(2):95-99

Abstract PDF PT PDF EN Portuguese Text

Objective: To evaluate the use of ex vivo lung perfusion (EVLP) clinically to prepare donor lungs for transplantation. Methods: A prospective study involving EVLP for the reconditioning of extended-criteria donor lungs, the criteria for which include aspects such as a PaO2/FiO2 ratio < 300 mmHg. Between February of 2013 and February of 2014, the lungs of five donors were submitted to EVLP for up to 4 h each. During EVLP, respiratory mechanics were continuously evaluated. Once every hour during the procedure, samples of the perfusate were collected and the function of the lungs was evaluated. Results: The mean PaO2 of the recovered lungs was 262.9 ± 119.7 mmHg at baseline, compared with 357.0 ± 108.5 mmHg after 3 h of EVLP. The mean oxygenation capacity of the lungs improved slightly over the first 3 h of EVLP-246.1 ± 35.1, 257.9 ± 48.9, and 288.8 ± 120.5 mmHg after 1, 2, and 3 h, respectively-without significant differences among the time points (p = 0.508). The mean static compliance was 63.0 ± 18.7 mmHg, 75.6 ± 25.4 mmHg, and 70.4 ± 28.0 mmHg after 1, 2, and 3 h, respectively, with a significant improvement from hour 1 to hour 2 (p = 0.029) but not from hour 2 to hour 3 (p = 0.059). Pulmonary vascular resistance remained stable during EVLP, with no differences among time points (p = 0.284). Conclusions: Although the lungs evaluated remained under physiological conditions, the EVLP protocol did not effectively improve lung function, thus precluding transplantation.

 


Keywords: Lung transplantation; Organ preservation; Brain death; Donor selection.

 


Pulmonary artery aneurysm as a manifestation of Behçet disease: case report and review

Aneurisma de artéria pulmonar como manifestação da doença de Behçet

Marcos Naoyuki Samano, Renata Teixeira Ladeira, Luiz Pedro Meirelles, Paulo Manuel Pêgo-Fernandes

J Bras Pneumol.2002;28(3):150-154

Abstract PDF PT

Behçet disease has been associated to pulmonary manifestations and may be lethal if not treated correctly. The authors describe a case of a 53 year-old male with aneurysmatic pulmonary artery dilatation, pulmonary hypertension, and hemoptysis. A review is presented about the diagnosis and the medical and surgical treatment of this disease.

 


Keywords: Behcet's syndrome. Pulmonary artery. Pulmonary hypertension. Aneurysm. Hemoptysis.

 


Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Citocinas no líquido pleural após transplante pulmonar como marcadores de rejeição aguda

Priscila Cilene León Bueno de Camargo, José Eduardo Afonso Jr, Marcos Naoyuki Samano, Milena Marques Pagliarelli Acencio, Leila Antonangelo, Ricardo Henrique de Oliveira Braga Teixeira

J Bras Pneumol.2014;40(4):425-428

Abstract PDF PT PDF EN Portuguese Text

Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.

 


Keywords: Lung transplantation; Pleural effusion; Cytokines; Graft rejection.

 


Psychological criteria for contraindication in lung transplant candidates: a five-year study

Critérios psicológicos para contraindicação em candidatos a transplante pulmonar: um estudo de cinco anos

Elaine Marques Hojaij1, Bellkiss Wilma Romano1, André Nathan Costa2, Jose Eduardo Afonso Junior3, Priscila Cilene Leon Bueno de Camargo3, Rafael Medeiros Carraro3, Silvia Vidal Campos4, Marcos Naoyuki Samano5, Ricardo Henrique de Oliveira Braga Teixeira6

J Bras Pneumol.2015;41(3):246-249

Abstract PDF PT PDF EN Portuguese Text

Lung transplantation presents a wide range of challenges for multidisciplinary teams that manage the care of the recipients. Transplant teams should perform a thorough evaluation of transplant candidates, in order to ensure the best possible post-transplant outcomes. That is especially true for the psychologist, because psychological issues can arise at any point during the perioperative period. The objective of our study was to evaluate the psychological causes of contraindication to waiting list inclusion in a referral program for lung transplantation. We retrospectively analyzed data on psychological issues presented by lung transplant candidates, in order to understand these matters in our population and to reflect upon ways to improve the selection process.

 


Keywords: Lung transplantation; Interview, psychological; Psychological tests; Preoperative care.

 


Diagnosis and treatment of mediastinal tumors by thoracoscopy

Diagnóstico e tratamento dos tumores mediastinais por toracoscopia

José Ribas Milanez de Campos, Luís Marcelo Inaco Cirino, Angelo Fernandez, Marcos Naoyuki Samano, Paulo Pego Fernandez, Luiz Tarcísio Britto Filomeno, Fábio Biscegli Jatene

J Bras Pneumol.2000;26(4):169-174

Abstract PDF PT

Objectives: Thoracoscopic management of mediastinal tumors is still subject to analysis. Seventy-three patients were submitted to thoracoscopy for the treatment of mediastinal masses and were analyzed retrospectively, in order to evaluate the effectiveness and complications of the procedure. Methods: Between 1983 and 1999, 21 conventional thoracoscopies and 52 video-assisted thoracic surgeries were performed (33 for diagnostic purposes and 40 for therapy). Patient ages ranged from two to 81 years (mean 43.8) with a slight predominance of females over males (41 versus 32). All underwent general anesthesia using simple (22) or double lumen (51) intubation. Results: The histological type of tumor was identified in all patients. For therapeutic purposes, conversion to thoracotomy was necessary in nine patients. The reasons were tumor size and invasion of nearby structures, difficulty to continue dissection, to perform an upper lobectomy, and to suture the iatrogenic diaphragm lesion. Four patients died during the first 30 postoperative days as a consequence of their primary pathology. Conclusions: Thoracoscopy was confirmed to be an effective diagnostic and therapeutic alternative for the treatment of mediastinal disorders.

 


Keywords: Thoracoscopy, thoracic surgery, mediastinal neoplasms, mediastinal cysts.

 


Postpneumonectomy pulmonary edema

Edema pulmonar pós-pneumonectomia

Marcos Naoyuki Samano, Luis Miguel Melero Sancho, Ricardo Beyruti, Fábio Biesegli Jatene

J Bras Pneumol.2005;31(1):-

Abstract PDF PT PDF EN Portuguese Text

Although pneumonectomy is a technically simple procedure, it has been associated with a high (60%) incidence of complications. Respiratory complications account for approximately 15% of such complications. Worldwide, the mortality rate among patients subjected to pneumonectomy is 8.6%. However, the rate among patients developing respiratory complications is 30%. Although postpneumonectomy pulmonary edema is rare (occurring in 3% to 5% of cases), it is a serious complication and is almost always fatal. It was first described twenty years ago and, despite these alarming statistics, little is known regarding the physiopathology of postpneumonectomy pulmonary edema. Once it has become entrenched, the condition is difficult to treat, and there is no proven efficient treatment. Various risk factors have been correlated with postpneumonectomy pulmonary edema onset. Fluid overload was the first to be identified as a factor to avoid. However, many studies have shown that there is no direct correlation between fluid overload and the development of edema. Prevention is the best way to avoid postpneumonectomy pulmonary edema and must be performed in a multidisciplinary fashion, involving the entire medical staff - from the initiation of anesthesia through the surgical procedure and extending into the critical care management phase. Equally important is early identification and testing of patients at risk for postpneumonectomy pulmonary edema when there is clinical suspicion of this serious complication.

 


Keywords: Key Words: Pulmonary edema/complications. Pneumonectomy/adverse effects. Risk factors. Pulmonary edema/prevention & control.

 


Lung hyperinflation after single lung transplantation to treat emphysema

Hiperinsuflação pulmonar após transplante unilateral por enfisema

Marcos Naoyuki Samano, Jader Joel Machado Junqueira, Ricardo Henrique de Oliveira Braga Teixeira, Marlova Luzzi Caramori, Paulo Manuel Pêgo-Fernandes, Fabio Biscegli Jatene

J Bras Pneumol.2010;36(2):265-269

Abstract PDF PT PDF EN Portuguese Text

Despite preventive measures, lung hyperinflation is a relatively common complication following single lung transplantation to treat pulmonary emphysema. The progressive compression of the graft can cause mediastinal shift and respiratory failure. In addition to therapeutic strategies such as independent ventilation, the treatment consists of the reduction of native lung volume by means of lobectomy or lung volume reduction surgery. We report two cases of native lung hyperinflation after single lung transplantation. Both cases were treated by means of lobectomy or lung volume reduction surgery.

 


Keywords: Lung transplantation; Postoperative complications; Pulmonary emphysema; Pneumonectomy.

 


Lung donor profile in the state of São Paulo, Brazil, in 2006

Perfil do doador de pulmão disponibilizado no estado de São Paulo, Brasil, em 2006

Paulo Manuel Pêgo Fernandes, Marcos Naoyuki Samano, Jader Joel Machado Junqueira, Daniel Reis Waisberg, Gustavo Sousa Noleto, Fabio Biscegli Jatene

J Bras Pneumol.2008;34(7):497-505

Abstract PDF PT PDF EN Portuguese Text

Objective: To analyze the rate at which lungs available for transplantation in the state of São Paulo in 2006 were utilized and to determine the lung donor profile in the same period. Methods: A retrospective study of 497 clinical charts of lung tissue donors from January to December of 2006. Results: According to the clinical charts, lungs were not offered for transplant in 149 cases (30%), which were therefore excluded from the study. Among the 348 lung donors eligible for inclusion in the study, the mean age was 37.4 ± 16.1 years, and 56.9% were males. The main causes of brain death among the donors were stroke (in 40.5%), skull-brain trauma (in 34.2%) and subarachnoid hemorrhage (in 10.9%). The great majority of these lung donors (90.5%) received vasoactive agents, and 13.5% presented cardiopulmonary arrest. The mean donor leukocyte count was 15,008 ± 6,467 cells/mm3, 67.8% of the donors received anti-bacterial agents, and 26.1% presented lung infection. Nearly 40% of the lung donors presented chest X-ray abnormalities. Only 4.9% of the lung donors were accepted, representing 28 lungs (allograft utilization rate of 4%). The causes for donor exclusion were gas exchange alterations (in 30.1%), infection (in 23.7%) and distance (in 10.9%). Conclusions: The lung utilization rate in the state of São Paulo is low when compared to mean rates worldwide. In addition, more than half of the donor pool was excluded due to altered gas exchange or pulmonary infection. The combination of better care of the potential donor and more flexible selection criteria could increase allograft utilization.

 


Keywords: Lung transplantation; Donor selection; Tissue donors.

 


Ex vivo lung perfusion: initial Brazilian experience

Perfusão pulmonar ex vivo: experiência nacional inicial

Paulo Manuel Pêgo-Fernandes, Israel Lopes de Medeiros, Alessandro Wasum Mariani, Flávio Guimarães Fernandes, Fernando do Valle Unterpertinger, Marcos Naoyuki Samano, Eduardo de Campos Werebe, Fábio Biscegli Jatene

J Bras Pneumol.2009;35(11):1107-1111

Abstract PDF PT PDF EN Portuguese Text

In the last 20 years, lung transplantation has become the standard treatment for patients with end-stage lung disease. However, less than 20% of the donor lungs available for transplant are actually usable. This disparity between the growing number of recipients and the small number of donors has resulted in increased mortality among lung transplant candidates on waiting lists. Strategies such as the utilization of organs from marginal donors have proven ineffective in increasing the number of transplants. In 2000, a new method for reconditioning human lungs that had been previously rejected for transplantation was developed in Sweden. We describe our initial experience with ex vivo lung perfusion.

 


Keywords: Lung transplantation; Organ preservation; Organ preservation solutions; Thoracic surgery.

 


Lung transplantation with extracorporeal membrane oxygenation as intraoperative support

Transplante pulmonar com oxigenação extracorpórea por membrana como suporte intraoperatório

Mariana Schettini-Soares1,a, Pedro Henrique Cunha Leite1,b, Ludhmila Abrahão Hajjar2,c, André Nathan Costa3,d, Paulo Manuel Pêgo-Fernandes1,e, Marcos Naoyuki Samano1,f

J Bras Pneumol.2018;44(5):442-444

PDF PT PDF EN Portuguese Text



Lung transplantation: overall approach regarding its major aspects.

Transplante pulmonar: abordagem geral sobre seus principais aspectos.

Priscila Cilene León Bueno de Camargo1, Ricardo Henrique de Oliveira Braga Teixeira1, Rafael Medeiros Carraro1, Silvia Vidal Campos1, José Eduardo Afonso Junior1, André Nathan Costa1, Lucas Matos Fernandes1, Luis Gustavo Abdalla1, Marcos Naoyuki Samano1, Paulo Manuel Pêgo-Fernandes1,2

J Bras Pneumol.2015;41(6):547-553

Abstract PDF PT PDF EN Portuguese Text Appendix



Treatment of bronchial stenosis after lung transplantation using a self-expanding metal endobronchial stent

Utilização de endoprótese metálica no tratamento de estenose brônquica após transplante pulmonar

Marcos Naoyuki Samano, Marlova Luzzi Caramori, Ricardo Henrique de Oliveira Braga Teixeira, Helio Minamoto, Paulo Manuel Pêgo Fernandes, Fabio Biscegli Jatene, Sérgio Almeida de Oliveira

J Bras Pneumol.2005;31(3):269-272

Abstract PDF PT PDF EN Portuguese Text

Although the incidence of bronchial anastomosis as a complication of lung transplantation has decreased in recent years, it remains a significant cause of morbidity and mortality in these patients. Treatment options include balloon dilatation, laser photocoagulation, placement of a stent (silicone or metal), and performing a second operation. We report the case of a patient who presented bronchial stenosis after left lung transplantation and was treated with a self-expanding metal alloy (nitinol) stent (UltraflexÒ). Despite the fact that this was the first case of stenosis treated in this fashion in Brazil, the positive clinical response, in agreement with results reported in the literature, indicates that this treatment is a viable alternative in such cases.

 


Keywords: Lung transplantation. Tracheal stenosis. Prosthesis and implants. Stents. Postoperative complications.

 


 

 


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