Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713


Publication continuous and bimonthly

SCImago Journal & Country Rank
Advanced Search

Year 2018 - Volume 44  - Number 3  (May/June)


Continuing Education: Imaging

6 - Unilateral hyperlucent lung

Pulmão hipertransparente unilateral

Edson Marchiori1,a, Bruno Hochhegger2,b, Gláucia Zanetti1,c

J Bras Pneumol.2018;44(3):182

PDF PT PDF EN Portuguese Text

Original Article

8 - Relationship between availability of physiotherapy services and ICU costs

Relação entre a disponibilidade de serviços de fisioterapia e custos de UTI

Bruna Peruzzo Rotta1,2,a, Janete Maria da Silva2,3,b, Carolina Fu2,4,c, Juliana Barbosa Goulardins4,5,d, Ruy de Camargo Pires-Neto2,4,e, Clarice Tanaka2,4,f

J Bras Pneumol.2018;44(3):184-189

Abstract PDF PT PDF EN Portuguese Text

Objective: To determine whether 24-h availability of physiotherapy services decreases ICU costs in comparison with the standard 12 h/day availability among patients admitted to the ICU for the first time. Methods: This was an observational prevalence study involving 815 patients ≥ 18 years of age who had been on invasive mechanical ventilation (IMV) for ≥ 24 h and were discharged from an ICU to a ward at a tertiary teaching hospital in Brazil. The patients were divided into two groups according to h/day availability of physiotherapy services in the ICU: 24 h (PT-24; n = 332); and 12 h (PT-12; n = 483). The data collected included the reasons for hospital and ICU admissions; Acute Physiology and Chronic Health Evaluation II (APACHE II) score; IMV duration, ICU length of stay (ICU-LOS); and Omega score. Results: The severity of illness was similar in both groups. Round-the-clock availability of physiotherapy services was associated with shorter IMV durations and ICU-LOS, as well as with lower total, medical, and staff costs, in comparison with the standard 12 h/day availability. Conclusions: In the population studied, total costs and staff costs were lower in the PT-24 group than in the PT-12 group. The h/day availability of physiotherapy services was found to be a significant predictor of ICU costs.


Keywords: Intensive care units; Respiration, artificial; Respiratory therapy; Hospital costs.


9 - Reference values for the six-minute pegboard and ring test in healthy adults in Brazil

Valores de referência para o teste de argolas de seis minutos em adultos saudáveis no Brasil

Vanessa Pereira Lima1,2,a, Fabiana Damasceno Almeida3,4,b, Tania Janaudis-Ferreira5,6,c, Bianca Carmona3,4,d, Giane Amorim Ribeiro-Samora3,4,e, Marcelo Velloso3,4,f

J Bras Pneumol.2018;44(3):190-194

Abstract PDF PT PDF EN Portuguese Text

Objective: To determine reference values for the six-minute pegboard and ring test (6PBRT) in healthy adults in Brazil, correlating the results with arm length, circumference of the upper arm/forearm of the dominant arm, and the level of physical activity. Methods: The participants (all volunteers) performed two 6PBRTs, 30 min apart. They were instructed to move as many rings as possible in six minutes. The best test result was selected for data analysis. Results: The sample comprised 104 individuals, all over 30 years of age. Reference values were reported by age bracket. We found that age correlated with 6PBRT results. The number of rings moved was higher in the 30- to 39-year age group than in the > 80-year age group (430.25 ± 77.00 vs. 265.00 ± 65.75), and the difference was significant (p < 0.05). The 6PBRT results showed a weak, positive correlation with the level of physical activity (r = 0.358; p < 0.05) but did not correlate significantly with any other variable studied. Conclusions: In this study, we were able to determine reference values for the 6PBRT in healthy adults in Brazil. There was a correlation between 6PBRT results and age.


Keywords: Upper extremity; Physical endurance; Exercise tolerance; Exercise test.


10 - Comparison of two smoking cessation interventions for inpatients

Comparação de duas intervenções de cessação do tabagismo em pacientes internados

Antonio Carlos Ferreira Campos1,a, Angela Santos Ferreira Nani2,b, Vilma Aparecida da Silva Fonseca3,c, Eduardo Nani Silva1,2,d, Marcos César Santos de Castro2,4,e, Wolney de Andrade Martins1,2,f

J Bras Pneumol.2018;44(3):195-201

Abstract PDF PT PDF EN Portuguese Text

Objective: This study aimed to compare the effectiveness of two cognitive behavioral therapy-based smoking cessation interventions initiated during hospitalization and to evaluate the factors related to relapse after discharge. Methods: This was a prospective randomized study involving 90 smokers hospitalized in a university hospital. We collected data related to sociodemographic characteristics, reasons for admission, smoking-related diseases, smoking history, the degree of nicotine dependence (ND), and the level of craving. Patients were divided into two treatment groups: brief intervention (BrInter, n = 45); and intensive intervention with presentation of an educational video (InInterV, n=45). To assess relapse, all patients were assessed by telephone interview in the first, third, and sixth months after discharge. Abstinence was confirmed by measurement of exhaled carbon monoxide (eCO). Results: Of the 90 patients evaluated, 55 (61.1%) were male. The mean age was 51.1 ± 12.2 years. The degree of ND was elevated in 39 (43.4%), and withdrawal symptoms were present in 53 (58.9%). The mean eCO at baseline was 4.8 ± 4.5 ppm. The eCO correlated positively with the degree of ND (r = 0.244; p = 0.02) and negatively with the number of smoke-free days (r = −0.284; p = 0.006). There were no differences between the groups in terms of the variables related to socioeconomic status, smoking history, or hospitalization. Of the 81 patients evaluated at 6 months, 33 (40.7%) remained abstinent (9 and 24 BrInter and InInterV group patients, respectively; p = 0.001), and 48 (59.3%) had relapsed (31 and 17 BrInter and InInterV group patients, respectively; p= 0.001). Moderate or intense craving was a significant independent risk factor for relapse, with a relative risk of 4.0 (95% CI: 1.5-10.7; p < 0.00001). Conclusions: The inclusion of an educational video proved effective in reducing relapse rates. Craving is a significant risk factor for relapse.


Keywords: Smoking cessation; Tobacco use disorder; Inpatients; Hospitalization.


11 - The triad of obstructive sleep apnea syndrome, COPD, and obesity: sensitivity of sleep scales and respiratory questionnaires

Tríade síndrome da apneia obstrutiva do sono, DPOC e obesidade: sensibilidade de escalas de sono e de questionários respiratórios

Flávio Danilo Mungo Pissulin1,a, Francis Lopes Pacagnelli1,b, Maiara Almeida Aldá1,c, Ricardo Beneti1,d, Jefferson Luis de Barros2,e, Suzana Tanni Minamoto2,f, Silke Anna Thereza Weber2,g

J Bras Pneumol.2018;44(3):202-206

Abstract PDF PT PDF EN Portuguese Text

Objective: To investigate whether the presence of obstructive sleep apnea syndrome (OSAS) alters the perception of respiratory symptoms and quality of life in COPD patients, by using specific questionnaires, as well as to determine whether scales for assessing daytime sleepiness and for screening for OSAS can be used in the triad of OSAS, COPD, and obesity. Methods: We included 66 patients diagnosed with mild-to-moderate or severe COPD and presenting with a body mass index > 27 kg/m2. After polysomnography, patients completed the Epworth sleepiness scale (ESS), the Berlin questionnaire (BQ), the modified Medical Research Council (mMRC) scale, the Baseline Dyspnea Index (BDI), and the Saint George's Respiratory Questionnaire (SGRQ). Results: Patients were first divided into two groups: COPD + OSAS (n = 46); and COPD-only (n = 20). The COPD + OSAS group was subdivided into a COPD + mild-to-moderate OSAS group (n = 32) and a COPD + severe OSAS group (n = 14), all of which were compared with the COPD-only group. There was a significant difference in mean FEV1 (L) between the COPD + OSAS groups and the COPD-only group (p = 0.073). The presence of the triad did not lead to significantly higher ESS scores, and scores > 10 had a specificity of 0.58. The BQ did not identify high risk for OSAS in the presence of the triad (specificity of 0.31). There were no significant differences in domain or total scores of the SGRQ between the COPD + OSAS groups and the COPD-only group. Conclusions: The confounding factors present in the triad of OSAS, COPD, and obesity prevented the perception of increased daytime sleepiness and high risk for OSAS. We observed no worsening of dyspnea perception or quality of life.


Keywords: Sleep apnea, obstructive; Pulmonary disease, chronic obstructive; Obesity; Surveys and questionnaires.


12 - Obesity and asthma: clinical and laboratory characterization of a common combination

Obesidade e asma: caracterização clínica e laboratorial de uma associação frequente

Juliana Pires Viana de Jesus1,2,a, Aline Silva Lima-Matos2,3,b, Paula Cristina Andrade Almeida2,c, Valmar Bião Lima2,d, Luane Marques de Mello4,e, Adelmir Souza-Machado2,5,f, Eduardo Vieira Ponte5,6,g, Álvaro Augusto Cruz2,7,h

J Bras Pneumol.2018;44(3):207-212

Abstract PDF PT PDF EN Portuguese Text

Objective: To evaluate the relationship between obesity and asthma. Methods: This was a preliminary cross-sectional analysis involving 925 subjects with mild-to-moderate or severe asthma evaluated between 2013 and 2015. Obesity was defined on the basis of body mass index (BMI) and abdominal circumference. We collected clinical, laboratory, and anthropometric parameters, as well as pulmonary function test results and data regarding comorbidities. The subjects also completed asthma control and quality of life questionnaires. Results: Obese individuals had a significantly higher number of neutrophils in peripheral blood than did nonobese individuals (p = 0.01). Among the obese individuals, 163 (61%) had positive skin-prick test results, as did 69% and 71% of the individuals classified as being overweight or normal weight, respectively. Obese individuals showed lower spirometric values than did nonobese individuals, and 32% of the obese individuals had uncontrolled asthma, a significantly higher proportion than that found in the other groups (p = 0.02). Conclusions: Obese individuals with asthma seem to present with poorer asthma control and lower pulmonary function values than do nonobese individuals. The proportion of subjects with nonatopic asthma was higher in the obese group. Our results suggest that obese individuals with asthma show a distinct inflammatory pattern and are more likely to present with difficult-to-control asthma than are nonobese individuals.


Keywords: Asthma; Obesity; Overweight; Eosinophilia.


13 - Is the COPD Assessment Test sensitive for differentiating COPD patients from active smokers and nonsmokers without lung function impairment? A population-based study

O COPD Assessment Test é sensível para diferenciar pacientes com DPOC de indivíduos tabagistas e não tabagistas sem a doença? Um estudo de base populacional

Manuela Karloh1,2,a, Simone Aparecida Vieira Rocha1,b, Marcia Margaret Menezes Pizzichini1,3,c, Francine Cavalli1,d, Darlan Laurício Matte1,2,4,e, Emilio Pizzichini1,3,f; The Respira Floripa Group

J Bras Pneumol.2018;44(3):213-219

Abstract PDF PT PDF EN Portuguese Text

Objective: To assess COPD Assessment Test (CAT) scores in adults with and without COPD, as well as to compare the CAT scores for nonsmokers, former smokers, and smokers without COPD with those for patients with COPD. Methods: This was a cross-sectional population-based study (the Respira Floripa study). The study included adults ≥ 40 years of age residing in the city of Florianópolis, Brazil. A total of 846 households were surveyed. In addition to completing the Respira Floripa questionnaire and the CAT, participants underwent pulmonary function testing. Results: We analyzed data on 1,057 participants (88.1% of the predicted sample size). A functional diagnosis of COPD was made in 92 participants (8.7%). Of those, 72% were unaware that they had COPD. The mean CAT score was higher in the group of COPD patients than in that of individuals without COPD (10.6 [95% CI: 8.8-12.4] vs. 6.6 [95% CI: 6.1-7.0]; p < 0.01). Individual item scores were significantly higher in the patients with COPD than in the individuals without COPD (p < 0.001), the exception being the scores for the items related to sleep (p = 0.13) and energy (p = 0.08). The mean CAT score was higher in the group of COPD patients than in nonsmokers (5.8 [95% CI: 5.3-6.4]) and former smokers (6.4 [95% CI: 5.6-7.2]; p < 0.05). However, there were no significant differences in the mean CAT score between the group of COPD patients and smokers without COPD (9.5 [95% CI: 8.2-10.8]; p > 0.05), the exception being the mean scores for confidence leaving home (p = 0.02). Conclusions: CAT scores were higher in the group of patients with COPD than in nonsmokers and former smokers without COPD. However, there were no significant differences in CAT scores between COPD patients and smokers without COPD. Smokers with an FEV1/FVC ratio > 0.70 have impaired health status and respiratory symptoms similar to those observed in COPD patients.


Keywords: Respiratory function tests; Pulmonary disease, chronic obstructive; Smoking.


14 - Validity and reliability of assessing diaphragmatic mobility by area on X-rays of healthy subjects

Validade e confiabilidade da avaliação da mobilidade diafragmática pelo método da área radiográfica em sujeitos saudáveis

Aline Pedrini1,a, Márcia Aparecida Gonçalves1,b, Bruna Estima Leal1,c, Michelle Gonçalves de Souza Tavares2,d, Wellington Pereira Yamaguti3,e, David Luiz Góes4,f, Elaine Paulin1,g

J Bras Pneumol.2018;44(3):220-226

Abstract PDF PT PDF EN Portuguese Text

Objective: To investigate the concurrent validity, as well as the intra- and inter-rater reliability, of assessing diaphragmatic mobility by area (DMarea) on chest X-rays of healthy adults. Methods: We evaluated anthropometric parameters, pulmonary function, and diaphragmatic mobility in 43 participants. Two observers (rater A and rater B) determined diaphragmatic mobility at two time points. We used Pearson's correlation coefficient to evaluate the correlation between DMarea and the assessment of diaphragmatic mobility by distance (DMdist). To evaluate intra- and inter-rater reliability, we used the intraclass correlation coefficient (ICC [2,1]), 95% CI, and Bland-Altman analysis. Results: A significant correlation was found between the DMarea and DMdist methods (r = 0.743; p < 0.0001). For DMarea, the intra-rater reliability was found to be quite high for the right hemidiaphragm (RHD)-ICC (2,1) = 0.92 (95% CI: 0.86-0.95) for rater A and ICC (2,1) = 0.90 (95% CI: 0.84-0.94) for rater B-and the left hemidiaphragm (LHD)-ICC (2,1) = 0.96 (95% CI: 0.93-0.97) for rater A and ICC (2,1) = 0.91 (95% CI: 0.81-0.95) for rater B-(p < 0.0001 for all). Also for DMarea, the inter-rater reliability was found to be quite high for the first and second evaluations of the RHD-ICC (2,1) = 0.99 (95% CI: 0.98-0.99) and ICC (2,1) = 0.95 (95% CI: 0.86-0.97), respectively-and the LHD-ICC (2,1) = 0.99 (95% CI: 0.98-0.99) and ICC (2,1) = 0.94 (95% CI: 0.87-0.97)-(p < 0.0001 for both). The Bland-Altman analysis showed good agreement between the mobility of the RHD and that of the LHD. Conclusions: The DMarea method proved to be a valid, reliable measure of diaphragmatic mobility.


Keywords: Diaphragm/physiology; Validation studies; Reproducibility of results; Radiography.


Brief Communication

15 - Mini-thoracostomy with vacuum-assisted closure: a minimally invasive alternative to open-window thoracostomy

Minipleurostomia com curativo a vácuo: uma opção minimamente invasiva a pleurostomia

Alessandro Wasum Mariani1,a, João Bruno Ribeiro Machado Lisboa1,b, Guilherme de Abreu Rodrigues1,c, Ester Moraes Avila2,d, Ricardo Mingarini Terra1,e, Paulo Manuel Pêgo-Fernandes1,f

J Bras Pneumol.2018;44(3):227-230

Abstract PDF PT PDF EN Portuguese Text

Thoracostomy is a common treatment option for patients with stage III pleural empyema who do not tolerate pulmonary decortication. However, thoracostomy is considered mutilating because it involves a thoracic stoma, the closure of which can take years or require further surgery. A new, minimally invasive technique that uses the vacuum-assisted closure has been proposed as an alternative to thoracostomy. This study aims to analyze the safety and effectiveness of mini-thoracostomy with vacuum-assisted closure in an initial sample of patients.


Keywords: Infection; Empyema, pleural; Negative-pressure wound therapy; Thoracostomy.


Case Series

16 - Characterization and outcomes of pulmonary alveolar proteinosis in Brazil: a case series

Proteinose alveolar pulmonar: caracterização e desfechos em uma série de casos no Brasil

Rodolfo Augusto Bacelar de Athayde1,a, Fábio Eiji Arimura1,b, Ronaldo Adib Kairalla1,c, Carlos Roberto Ribeiro Carvalho1,d, Bruno Guedes Baldi1,e

J Bras Pneumol.2018;44(3):231-236

Abstract PDF PT PDF EN Portuguese Text

Objective: Pulmonary alveolar proteinosis (PAP) is a rare disease, characterized by the alveolar accumulation of surfactant, which is composed of proteins and lipids. PAP is caused by a deficit of macrophage activity, for which the main treatment is whole-lung lavage (WLL). We report the experience at a referral center for PAP in Brazil. Methods: This was a retrospective study involving patients with PAP followed between 2002 and 2016. We analyzed information regarding clinical history, diagnostic methods, treatments, and outcomes, as well as data on lung function, survival, and complications. Results: We evaluated 12 patients (8 of whom were women). The mean age was 41 ± 15 years. Most of the patients were diagnosed by means of BAL and transbronchial biopsy. The mean number of WLLs performed per patient was 2.8 ± 2.5. One third of the patients never underwent WLL. Four patients (33.3%) had associated infections (cryptococcosis, in 2; nocardiosis, in 1; and tuberculosis, in 1), and 2 (16.6%) died: 1 due to lepidic adenocarcinoma and 1 due to complications during anesthesia prior to WLL. When we compared baseline data with those obtained at the end of the follow-up period, there were no significant differences in the functional data, although there was a trend toward an increase in SpO2. The median follow-up period was 45 months (range, 1-184 months). The 5-year survival rate was 82%. Conclusions: To our knowledge, this is the largest case series of patients with PAP ever conducted in Brazil. The survival rate was similar to that found at other centers. For symptomatic, hypoxemic patients, the treatment of choice is still WLL. Precautions should be taken in order to avoid complications, especially opportunistic infections.


Review Article

17 - Reperfusion in acute pulmonary thromboembolism

Reperfusão no tromboembolismo pulmonar agudo

Caio Julio Cesar dos Santos Fernandes1,2,a, Carlos Vianna Poyares Jardim1,b, José Leonidas Alves Jr1,2,c, Francisca Alexandra Gavilanes Oleas1,d, Luciana Tamie Kato Morinaga1,e, Rogério de Souza1,f

J Bras Pneumol.2018;44(3):237-243

Abstract PDF PT PDF EN Portuguese Text

Acute pulmonary thromboembolism (APTE) is a highly prevalent condition (104-183 cases per 100,000 person-years) and is potentially fatal. Approximately 20% of patients with APTE are hypotensive, being considered at high risk of death. In such patients, immediate lung reperfusion is necessary in order to reduce right ventricular afterload and to restore hemodynamic stability. To reduce pulmonary vascular resistance in APTE and, consequently, to improve right ventricular function, lung reperfusion strategies have been developed over time and widely studied in recent years. In this review, we focus on advances in the indication and use of systemic thrombolytic agents, as well as lung reperfusion via endovascular and classical surgical approaches, in APTE.


Keywords: Embolism; Shock; Hypotension; Thrombolytic therapy; Reperfusion; Hemorrhage.


Images in Pulmonary Medicine

18 - Fat embolism syndrome: chest CT findings

Síndrome da embolia gordurosa: achados de TC de tórax

Alessandro Graziani1,a, Chiara Carli Moretti2,b, Federica Mirici Cappa3,c

J Bras Pneumol.2018;44(3):244

PDF PT PDF EN Portuguese Text

Author's reply

22 - Authors' reply

Resposta dos autores

Marcelo Fouad Rabahi1,a, José Laerte Rodrigues da Silva Júnior2,3,b, Marcus Barreto Conde4,5,c

J Bras Pneumol.2018;44(3):251-252

PDF PT PDF EN Portuguese Text


The Brazilian Journal of Pulmonology is indexed in:

Latindex Lilacs SciELO PubMed ISI Scopus Copernicus pmc


CNPq, Capes, Ministério da Educação, Ministério da Ciência e Tecnologia, Governo Federal, Brasil, País Rico é País sem Pobreza
Secretariat of the Brazilian Journal of Pulmonology
SCS Quadra 01, Bloco K, Salas 203/204 Ed. Denasa. CEP: 70.398-900 - Brasília - DF
Fone/fax: 0800 61 6218/ (55) (61) 3245 1030/ (55) (61) 3245 6218

Copyright 2019 - Brazilian Thoracic Association

Logo GN1