ABSTRACT

Two spacer devices for aerosol inhalation were compared by a crossover study of FEV 1 response to 200 μg of salbutamol in 20 asthmatics evaluated in separate days. Fisonair ® (750 ml reservoir) use led to an average 0.32 L increase in FEV 1, which was significantly higher than the 0.26 L obtained with Jet® (103 ml reservoir) (p = 0.02). Bronchodilator response with Jet® was 21% lower (CI: -7 to -35%) than with Fisonair ® .

Keywords: Asthma. Aerosols. Delivery systems.

RESUMO

Vinte pacientes com obstrução reversível ao fluxo aéreo foram avaliados de modo cruzado em dias diferentes quanto à resposta ao salbutamol 200mcg, administrado por diferentes câmaras de expansão: Jet (103ml) e grande câmara de suspensão Fisonair (750ml). Houve maior aumento da resposta com Fisonair: 0,32L comparado com Jet: 0,26L (p = 0,02). A resposta com Jet foi 21% menor (IC: -7 a -35%).

Palavras-chave: Asma. Aerossóis. Espaçadores.

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